Osteoporosis – Cannabis Compound Hardens Bone
Another study paper has only been released that demonstrates how plant based chemicals can help contain the fragile bone disease, osteoporosis. Researchers at the Institute of Medical Sciences, University of Aberdeen, UK have found the way the non-psychoactive chemical in cannabis, cannabidiol can help maintain bone strength.
The endocannabinoid process is a set of mobile receptors which are activated by means of a set of endogenous lipids in addition to compounds derived from the cannabis plant cbd tincture. The cannabinoid receptors have been involved with a number of physiological processes such as hunger control, pain, mood and memory.
Recent studies have proven that the endocannabinoid system has a powerful influence on bone metabolism, as the receptors have been nicely represented on osteoclasts – cells whose main purpose is to resorb (lean out) bone.
Bone is an active, living tissue which has been constantly shaped, remodeled and formed in reaction to the physiological and physical demands of the human body.
Bone matrix is made up chiefly of the macronutrients magnesium, calcium and phosphate and is also the substance which makes up the dense areas of the bone and the bone marrow frame.
A lot of individuals still feel that if a person eats foods rich in these minerals then they are going to prevent osteoporosis. Epidemiological and other evidence indicates that this isn’t necessarily the situation.
1) Osteoblasts are bone cells which are responsible for the creation of bone matrix
Both of these cell types are regulated by a intricate group of signaling proteins, hormones and cell receptors which react to the ever-changing needs on bone tissue as well as other physiological processes.
If there are numerous osteoclasts, or when those cells become contagious, then they will resorb more matrix compared to the osteoblasts may create. A predominance of osteoclast action ends in the bone getting less dense – that the primary feature of this clinical condition called osteoporosis.
The Aberdeen scientists have found that cannabidiol binds to a particular cannabinoid receptor on the bone-resorbing osteoblast cells. By doing this inhibits these cells out of resorbing the bone matrix – thus helping to prevent additional weakening of bones.
This isn’t the first time that plant chemicals have been proven to affect bone metabolism in favour of more powerful bones. In January 2009 researchers at Oklahoma State University in the USA discovered that, in the presence of oxidative stress and systemic inflammation, polyphenols derived from plums inhibit the activity of their bone-softening osteoclasts but boost the production and action of both bone-building osteoblasts.